Combination therapy for cancer with oncolytic virus and checkpoint inhibitor: A mathematical model.
Oncolytic virus (OV) is a replication competent virus that selectively invades cancer cells; as these cells die under the viral burden, the released virus particles proceed to infect click here other cancer cells.Oncolytic viruses are designed to also be able to stimulate the anticancer immune response.Thus, one may represent an OV by two parameter